The restaurant's last day of trading will be Saturday 25 May.
The Welsh chef and restaurateur took over Odette's in 2008 having previously worked at Orrery Restaurant on Marylebone High Street under head chef André Garrett. He shot to fame in 2006, beating a number of established chefs on the BBC’s Great British Menu.
"Sixteen years ago I bought Odette's restaurant in Primrose Hill, it's been my cooking home and I've loved every minute of it," says Williams. "Now, it's time to move on and explore new adventures."
"I would like to say a huge thank you to everyone who has worked at Odette's over the years and to all of our wonderful guests, many of whom were loyal for the last 16 years."
Alongside Odette's, Denbigh-raised Williams runs a beach-front restaurant, café and bar at Porth Eirias in Colwyn Bay and a restaurant at The Cambrian hotel in the Swiss Alps. He also oversees the food at Touring Club restaurant in Penarth, south Wales.
Earlier this month he announced that he will be opening a restaurant within Theatr Clwyd, Wales’ biggest producing theatre, in Flintshire, north wales, next year. He will oversee the food and drink offer at the entire venue, including its restaurants, bars, and event and retail spaces.
"I'm now excited to spend more time in my native Wales, and in particular North Wales, continuing to work on our bistro in Porth Eirias, as well as take on other opportunities further afield," adds Williams.
