Taking over the former The Mason's Arms site on Devonshire Street, which will be rebranded as The Lucky Saint, it will also feature a menu of 're-imagined classic pub food'.
The announcement comes after Lucky Saint recently completed a £10m fundraising round.
Spread over multiple floors, Lucky Saint plans to also use the site to house its London offices, acting as a hub for the business in the absence of a physical brewery site in the UK (Lucky Saint’s lager is brewed under licence in Germany).
As well as functioning as a pub, The Lucky Saint will host events throughout the year, from ride outs and run clubs around Regent’s Park, to creating a space to hold Mental Health First Aid (MHFA) England training.
Announcing the opening on LinkedIn, Lucky Saint managing director, Emma Heal, said: "We've learned so many good (and hard) lessons from our incredible friends and colleagues across UK Hospitality, and now we want to pay it forward.
"Our aim is to provide a warm, inclusive and inviting Community hub - 'a Pub for our times', and we can't wait to host you."