Jacuzzi will be the group's fourth London site and have 170 covers spread over four floors.
Housed in a former bank, the 4,000sq ft space will include a botanical mezzanine with retractable glass ceiling; alabaster walls; and stucco ceilings.
The basement level will feature the group's first 'disco toilet', complete with glitter ball and a 'cove of mirrors'.
Jacuzzi's menu will feature a typically indulgent selection of Italian dishes and include starters of cured ham from Onesto Ghiradi served with gnocchi fritti; burrata with fresh seasonal truffle; and pizzette topped with truffle, caviar and bottarga.
Mains, meanwhile, will feature lobster risotto with half lobster, clams, red gurnard and cuttlefish; and a sharing plate of truffle pasta with fresh black truffle, truffle cream and parmigiano foam, which is prepared tableside in a 4kg wheel of pecorino.
Desserts will include a 'decadent' chocolate fondue for two made with half a kilo of Valrhona chocolate.
Big Mamma, which is run by Tigrane Seydoux and Victor Lugger, launched in the capital in early 2019 with the opening of the 172-cover Gloria in Shoreditch. This was followed up with the opening of 300-cover Circolo Popolare in Fitzrovia’s Rathbone Place, which also opened in 2019; and Ave Mario, which opened in Covent Garden last summer.
The group also runs pizza delivery concept Napoli Gang, which has a single site in Ladbroke Grove.