In a statement, co-owner Ratnesh Bagdai confirmed the closure of the Curtain Road site, adding that the group was planning to open a new central London venue in the near future.
He said: “After ten very happy years, Brindisa will be moving from its Shoreditch restaurant in Curtain Road to pastures new.
“It’s been a great journey in the Shoreditch area but as always, as a small independent group we need to re-evaluate the estate from time to time.
“Details to follow in the coming weeks, of our new central London site.”
The closure in Shoreditch leaves Brindisa with a portfolio of five tapas restaurants across the capital including in Battersea, Borough Market, Soho and South Kensington.
Last year the group launched its first restaurant outside of central London, in Richmond.
The Brindisa brand was originally founded by Monika Linton in 1988 as a specialist wholesaler of Spanish food in London.
Bagdai joined the business in 2004 and later that year it launched its first tapas bar, in Borough Market. Bagdai is a well-known figure in the industry. As well as being the boss of restaurant accountancy firm RNB, also also owns The Bailiwick pub in Surrey.