The 354sq ft outlet will be 'based around functionality and speed', and will offer grab-and-go and delivery through platforms including Deliveroo, Uber Eats and Just Eat.
It will be the group's third site to operate under franchisee Mohammed Uddin, who also operates Creams restaurants in London’s Whitechapel and Southend.
Creams currently operates a 90-strong estate, the majority of which are run be independent franchisee partners.
The opening in Old Street comes just a couple of days after the group added another restaurant location to its portfolio, in Morden.
Operating under a different franchisee to the Old Street site, the Morden restaurant holds 48-covers with dine-in, delivery and takeaway available.
Designed by Design CLD, the interiors feature the brand’s signature gelato counter, booth seating and urban skateboard theme.
Both openings are are part of Creams' 'ambitious' expansion plan, which will see the group open 12 new UK stores over the next 12 months, whilst also advancing its plans for international expansion.
“Even with the impact of Covid-19, the brand has experienced exceptional sales and growth," says Creams CEO Adam Mani.
"Product innovation, improved supply chain, and of course, the hard work and passion of our internal team and franchisees means we are well-placed to continue with our plans to reach 100 stores in the next 12 months.”