The venue - which was formerly owned by Paul Adams and footballer Steven Gerrard - will trade seamlessly under the new management from today (April 2) and will relaunch as The Metropolitan Bar & Grill Rooms later in the year.
Byrne - who recently relaunched his Manchester fine dining venue as Restaurant MCR - is being backed by Medusa Hospitality.
As the name suggests, the new restaurant will have a relatively simple grill menu of "classic, honest food, delivered really well by the best team of chefs around".
“I have built my reputation with a fine dining tasting menu, however, I have always wanted to deliver a high-end grill rooms concept," says Byrne.
"The realisation of The Metropolitan Bar & Grill Rooms is a lifetime ambition to pay my respects to legendary venues like The Savoy Grill and The Grill at the Dorchester, who have set the standards for all to aspire to.
Byrne received his first Michelin star aged 22, and remains the youngest ever UK chef to win the accolade. His CV includes time with Tom Aikens, Paul Rankin and David Adlard.
His portfolio of venues also includes The Church Green British Grill in Lymm and the British Grill in the Macdonald Craxton Wood Hotel in Ledsham, both near Chester.