Property Week reports that the lease is on the market with a guide price of £180m.
The hotel last changed hands in 2014, when it was sold by Strategic Hotels & Resorts to Hong Kong-based private equity firm Joint Treasure for £125m.
Joint Treasure previously tried to sell its long leasehold on the site, which has less than 40 years remaining, in 2017.
The five-star hotel was home to Ramsay’s Maze restaurant for 14 years until it closed in February. The chef will relaunch the site as Asian-inspired concept Lucky Cat this summer.
Ramsay’s separate Maze Grill restaurant is still open at the hotel.