The restaurant will stop serving diners on 17 November, before transforming in to an events space.
A statement posted on The Rabbit’s Twitter account said the closure was due to a decision from its shareholders.
“From 18 November our unique space will be used for corporate and private events only and our team will continue to operate the venue under the GG Events and Catering brand,” the company said.
The restaurant opened as The Rabbit in the Moon in early 2017 while O’Hare was creative director of the business, which is backed by former footballers Gary Neville and Ryan Giggs, and was billed as a “space age Asian restaurant”.
It relaunched in March this year with O’Hare taking the reins in the kitchen, but the chef left the business to focus on his Michelin-starred Leeds restaurant The Man Behind The Curtain just a few months later.
The Rabbit in the Moon was tipped to win Manchester its first star since 1974, but missed out on the accolade two years in a row.
The closure comes weeks after the another fine dining restaurant in the city, Manchester House, shut its doors. The site's owner Living Ventures said it had struggled with “difficult trading” over the summer.