The 113-cover restaurant on St Vincent Street will be the group's eighth in the UK and will fulfill its ambitions to open in Scotland.
A second Scottish site - in Edinburgh - is set to follow in 2017.
Spanish designer Lazaro Rosa Violan has worked with the business to design the site, previously a Royal Bank of Scotland branch, with an emphasis on the Celtic heritage shared by Northern Spain and Scotland.
The Glasgow site, opening on 30 September, will serve the chain's range of regional Spanish food and drink curated by the group's executive head chef Nacho Manzano, including hand-carved hams and cheeses alongside beers, wines, sherries and ciders. It will also serve an exclusive dish - the Botillo from El Bierzo - a Spanish 'haggis' made of chopped and marinated cuts of pork, lightly smoked before cooking.
A bar menu will feature bocadillos and pinchos while a delicatessen will sell olive oils, hams, cured meats and more with freshly-made bocadillos available to take away.
Ibérica managing director Marcos Fernandez said: "With so many similarities between the north of Spain and Scotland, we’ve been very keen to connect with our Celtic roots and open a restaurant in Glasgow. We’re aware that there is a lively restaurant scene in the city and the people are always keen to try something new, so we’re sure the authentic, high-quality yet affordable dining experience we can offer at Ibérica will definitely be of interest."