Guests can choose from 11 different coffees from the brand’s premium Grand Cru range and mocktails including rose cappuccino, macaroon latte and mojito coffee.
Specially trained Nespresso Maestros will be on hand to advise customers on coffee and food matching suggestions, with premium paninis, salads, macaroons and pastries all on offer.
The 100 Cheapside venue is Nespresso’s first UK café launch following its successful pilot in Vienna last year.
“London has a thriving coffee culture but Café Nespresso is a unique premium café experience,” said Francisco Nogueira, managing director of Nespresso UK & Ireland.
“The UK is fast becoming a nation of coffee experts and as we grab our morning latte we want to know it is personalised to our tastes.
“Our Maestros will guide customers to find their perfect drink from a large array of recipes and combinations, creating an entertaining experience for all.”
Customers can also purchase a range of limited edition coffees from the UK’s first Nespresso Cube, a self-service machine with a robotised order-picking system.
An on-site recycling point will allow eco-friendly customers to return their used coffee capsules, though caffeine addicts can also organise a collection of their empty 'pods' from their own home.
The cafe is part of a joint venture between Nespresso and premium food caterer DO&CO.