The Irish group has signed a long-term lease on the former office building, located near the new Liverpool One retail development.
It is the latest opening to be added to the group’s fast-growing portfolio, with aparthotels set to launch in Marseille and York later this year.
When completed the Corn Exchange site will feature a guest laundry, fitness room, 53 parking spaces and an open-plan restaurant area.
The studio, one and two-bed apartments are expected to create up to 40 full and part-time jobs.
“Our European expansion will take us to 10,000 apartments by the end of 2021 but it’s important that we also have a strong foothold in the UK’s major cities,” said Staycity CEO Tom Walsh,
“Liverpool gives us a fantastic mix of leisure and corporate guests with a proven demand for aparthotels.”
Staycity runs aparthotels across eight cities in the UK and Europe, and will open properties in Lyon, Covent Garden and Manchester in 2017.
It already operates 56 apartments on Liverpool’s Duke Street, which opened in 2009.
According to a report by Savills, the UK's serviced apartment sector is set to double in size by 2017.
Staycity alone is opening 843 units this year.