The pair, who launched the first 28-50 on Fetter Lane in June 2010 as a more relaxed alternative to their original restaurant, will open their third venue on Maddox Street in September.
The 90-cover bar and restaurant will be situated over two floors and, as with its sibling restaurants, will serve French bistro style food and charcuterie alongside more than 30 wines available by the glass, carafe and bottles.
"We’re really excited at the prospect of opening in such a foodie hub – Maddox Street and the surrounding area has become a great spot for destination dining and we very much hope to be a part of that," the pair said.
"Having run 28-50 Marylebone for nearly a year now, we’re delighted to see that the West End has taken to the concept so we’re looking forward to the next opening in September."
Sverrisson, a chef and Rousset, a sommelier, met while working at Le Manoir aux Quat'Saisons where they held the positions of head chef and head sommelier respectively.
Together they opened Texture in 2007, a modern European restaurant with Scandinavian influences, which gained a Michelin star in 2007.
The pair opened their second 28-50 Wine Workshop & Kitchen in June 2012 following the success of their Fetter Lane venture.
Sverisson works with executive chef Paul Walsh to compile menus for the concept with Rousset responsible for sourcing and selecting the wines.